Anthony H Futerman Selected Research

dihydroceramide desaturase

3/2021	Ceramide Synthase 2 Null Mice Are Protected from Ovalbumin-Induced Asthma with Higher T Cell Receptor Signal Strength in CD4+ T Cells.
12/2017	Ablation of ceramide synthase 2 exacerbates dextran sodium sulphate-induced colitis in mice due to increased intestinal permeability.
1/2017	Jaspine B induces nonapoptotic cell death in gastric cancer cells independently of its inhibition of ceramide synthase.
1/2016	Effect of the sphingosine kinase 1 selective inhibitor, PF-543 on arterial and cardiac remodelling in a hypoxic model of pulmonary arterial hypertension.
8/2015	LPS-mediated septic shock is augmented in ceramide synthase 2 null mice due to elevated activity of TNFα-converting enzyme.
8/2015	Development of pheochromocytoma in ceramide synthase 2 null mice.
5/2015	Lack of ceramide synthase 2 suppresses the development of experimental autoimmune encephalomyelitis by impairing the migratory capacity of neutrophils.
10/2014	CerS2 haploinsufficiency inhibits β-oxidation and confers susceptibility to diet-induced steatohepatitis and insulin resistance.
4/2014	Bcl2L13 is a ceramide synthase inhibitor in glioblastoma.
2/2014	Reduced ceramide synthase 2 activity causes progressive myoclonic epilepsy.

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Anthony H Futerman Research Topics

Disease

39	Gaucher Disease (Gaucher's Disease) 01/2021 - 11/2002
14	Lysosomal Storage Diseases (Lysosomal Storage Disease) 07/2020 - 08/2002
9	Neoplasms (Cancer) 01/2022 - 07/2009
9	Inflammation (Inflammations) 03/2021 - 07/2009
8	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2021 - 08/2003
6	Sphingolipidoses (Sphingolipidosis) 06/2015 - 08/2002
5	Neuroinflammatory Diseases 01/2021 - 02/2014
5	Sandhoff Disease (Sandhoff's Disease) 01/2019 - 08/2003
4	Cardiovascular Diseases (Cardiovascular Disease) 01/2022 - 10/2014
3	Parkinson Disease (Parkinson's Disease) 01/2022 - 08/2011
3	Infections 01/2020 - 10/2013
3	Insulin Resistance 01/2015 - 02/2013
3	Epilepsy (Aura) 12/2010 - 09/2004
2	Vesicular Stomatitis 01/2021 - 01/2020
2	Type C Niemann-Pick Disease (Niemann Pick Disease, Type C) 01/2021 - 01/2019
2	Virus Diseases (Viral Diseases) 01/2021 - 01/2015
2	Mucolipidoses (Sialidosis) 01/2021 - 01/2018
2	Bacterial Infections (Bacterial Infection) 09/2020 - 01/2019
2	Globoid Cell Leukodystrophy (Krabbe Disease) 12/2016 - 07/2003
2	Neurologic Manifestations (Neurological Manifestations) 03/2015 - 02/2014
2	Obesity 01/2015 - 10/2014
2	Metabolic Diseases (Metabolic Disease) 10/2014 - 01/2013
2	Gliosis 08/2011 - 09/2010
2	Gangliosidoses (Gangliosidosis) 01/2008 - 08/2003
2	Disease Progression 04/2005 - 01/2004
1	Carcinoma (Carcinomatosis) 01/2022
1	Kidney Neoplasms (Kidney Cancer) 01/2022
1	Atherosclerosis 09/2021
1	Asthma (Bronchial Asthma) 03/2021
1	Non-alcoholic Fatty Liver Disease 11/2019
1	Colitis 12/2017
1	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 12/2017

Drug/Important Bio-Agent (IBA)

29	Glucosylceramidase (Glucocerebrosidase)IBA 01/2022 - 11/2002
24	EnzymesIBA 01/2022 - 07/2003
20	CeramidesIBA 01/2022 - 07/2009
16	Glucosylceramides (Glucocerebrosides)IBA 01/2022 - 11/2002
15	SphingolipidsIBA 01/2022 - 08/2002
13	dihydroceramide desaturaseIBA 03/2021 - 01/2010
10	LipidsIBA 01/2021 - 05/2003
6	GlycosphingolipidsIBA 01/2017 - 01/2004
5	Lysergic Acid Diethylamide (LSD)IBA 09/2020 - 04/2009
5	GangliosidesIBA 01/2019 - 08/2002
5	Biological ProductsIBA 12/2016 - 07/2003
5	CalciumIBA 07/2010 - 08/2003
4	Messenger RNA (mRNA)IBA 01/2022 - 01/2010
4	CytokinesIBA 03/2021 - 07/2009
4	SphingosineIBA 01/2021 - 09/2014
4	AcidsIBA 01/2017 - 10/2011
4	GlucosidasesIBA 01/2017 - 10/2011
4	HydrolasesIBA 06/2015 - 12/2010
3	Biomarkers (Surrogate Marker)IBA 01/2022 - 01/2015
3	CholesterolIBA 01/2019 - 01/2014
3	G(M2) Ganglioside (Ganglioside GM2)IBA 01/2019 - 08/2003
3	Proteins (Proteins, Gene)FDA Link 03/2015 - 02/2014
3	imiglucerase FDA Link 11/2008 - 12/2006
3	Sarcoplasmic Reticulum Calcium-Transporting ATPasesIBA 01/2008 - 08/2003
3	Phosphatidylcholines (Phosphatidylcholine)IBA 07/2007 - 11/2002
2	Glycoproteins (Glycoprotein)IBA 01/2021 - 01/2015
2	InterferonsIBA 09/2020 - 12/2016
2	Hexosaminidases (Hexosaminidase)IBA 01/2019 - 03/2006
2	Fingolimod Hydrochloride (FTY720)FDA Link 01/2018 - 09/2014
2	sortilinIBA 01/2017 - 01/2015
2	Glucose (Dextrose)FDA LinkGeneric 01/2017 - 01/2015
2	Interferon Type IIBA 12/2016 - 01/2015
2	sphingosine kinaseIBA 01/2016 - 01/2010
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 08/2015 - 07/2009
2	Insulin (Novolin)FDA Link 01/2015 - 02/2013
2	Insulin ReceptorIBA 01/2015 - 02/2013
2	Acid CeramidaseIBA 09/2014 - 01/2014
2	Galactosylceramides (Galactocerebrosides)IBA 08/2011 - 11/2002
2	lysosomal proteinsIBA 07/2010 - 08/2003
2	Polysaccharides (Glycans)IBA 11/2008 - 09/2007
2	miglustat (Zavesca)FDA Link 09/2007 - 08/2003
2	Choline-Phosphate CytidylyltransferaseIBA 07/2007 - 11/2002
2	Ryanodine Receptor Calcium Release Channel (Ryanodine Receptor)IBA 12/2005 - 02/2005
2	sphingosyl beta-glucosideIBA 02/2005 - 07/2003
2	Phospholipids (Phosphatides)FDA LinkGeneric 07/2004 - 07/2004
1	Acyl Coenzyme A (Acyl CoA)IBA 01/2022
1	RNA (Ribonucleic Acid)IBA 01/2022
1	5'- bromo- 5- phenyl- spiro(3H- 1,3,4- thiadiazole- 2,3'- indoline)- 2'- oneIBA 01/2022
1	Therapeutic UsesIBA 01/2022
1	dihydroceramideIBA 01/2022
1	T-Cell Antigen Receptors (T-Cell Receptor)IBA 03/2021
1	OvalbuminIBA 03/2021
1	Lipoproteins (Lipoprotein)IBA 01/2021
1	Transient Receptor Potential ChannelsIBA 01/2021
1	chenodeoxycholate sulfate conjugate (CDCS)IBA 01/2020
1	alpha E integrinsIBA 01/2020
1	Antiviral Agents (Antivirals)IBA 01/2020
1	Bortezomib (Velcade)FDA Link 11/2019
1	Membrane Proteins (Integral Membrane Proteins)IBA 01/2019
1	Lysosomal Membrane ProteinsIBA 01/2019
1	Phosphates (Orthophosphate)IBA 01/2018
1	SodiumIBA 12/2017
1	Dextrans (Dextran)FDA Link 12/2017
1	Clozapine (Clozaril)FDA LinkGeneric 03/2017
1	Antipsychotic Agents (Antipsychotics)IBA 03/2017

Therapy/Procedure

6	Therapeutics 01/2021 - 11/2008
6	Enzyme Replacement Therapy 01/2017 - 04/2005
2	Drug Therapy (Chemotherapy) 01/2022 - 07/2009